This article analyzes the behavioral abnormalities and pathological changes in brain tissue of rats after Trim44 gene knockout using Trim44 conditional knockout, and explores the mechanism of action o

This article aims to analyze the behavioral abnormalities and pathological changes in brain tissue of rats treated with Trim44 gene knockout, and explore the mechanism of action of Trim44 gene in the nervous system...

2023-06-13

【 Animal modeling 】 - The effect of acrylamide exposure during puberty on oxidative damage in mouse lung tissue

To investigate the damage of acrylamide to mouse lung tissue and its possible mechanism...

2023-06-13

[Animal modeling] - Xiaoyusan new formula for repairing cartilage damage and MMP-13 expression in knee Osteoarthritis model rabbits

To study the effect and mechanism of Xiaoyusan new formula on articular cartilage of knee Osteoarthritis rabbits...

2023-06-13

[Animal modeling] - Detection of protein expression profile in liver Histone of mice with alcoholic fatty liver disease and exploration of the intervention mechanism of Resveratrol

To analyze the changes of protein expression profile in liver Histone of mice with alcoholic fatty liver disease and the intervention effect of Resveratrol by Proteomics...

2023-06-13

[Animal modeling] - Application of ultrasound image in evaluating nodular Goitre in rats

To determine the thyroid localization of rats by using ultrasound technology, and analyze and evaluate the pathological changes and modeling degree of nodular Goitre model in rats, so as to provide technical methods for the diagnosis and evaluation o...

2023-06-13

[Animal modeling] - Taurine has no protective effect on corneal endothelial cells in rats injured by Benzalkonium chloride

To observe the protective effect of 2% taurine on endothelial cells of cornea injured by benzalkonium chloride in rats...

2023-06-13

【 Animal modeling 】 - The effect of aerobic exercise on the inhibitory synaptic transmission efficiency of dopamine neurons in VTA of nicotine withdrawal mice

To explore the effect of moderate intensity aerobic exercise on inhibitory Synaptic plasticity of VTA dopamine neurons in nicotine withdrawal mice, so as to provide some experimental evidence for reducing nicotine relapse by exercise...

2023-06-13

【 Traditional Chinese Medicine Model 】 - The Effect of Danggui Shengjiang Yangrou Tang on Traditional Chinese Medicine Syndrome of IBS-D Rats with Spleen and Kidney Yang Deficiency

To explore the traditional Chinese medicine syndrome manifestations of spleen and kidney yang deficiency model and observe the improvement effect of Danggui Shengjiang Yangrou Tang on traditional Chinese medicine syndrome in IBS-D female rats with sp...

2023-06-13

Study on the Effect of Traditional Chinese Medicine Relaxation Cream Combined with Exercise Rehabilitation on the ROM and Inflammatory Response of Joint Fibrosis in Rats with Joint Contracture

To explore the effect of traditional Chinese medicine relaxation cream combined with treadmill exercise rehabilitation intervention on ROM, IL-6, IL-17, and TGF in joint fibrosis of rats with joint contracture- β 1. The impact of expression...

2023-06-13

【 Animal Modeling 】 - Study on the Effect of Ischemia Time Difference on Intestinal Ischemia Reperfusion Injury in Rats

To evaluate the impact of small intestinal ischemia time on small intestinal ischemia-reperfusion models from the perspective of oxidative damage pathways and histopathology, and to provide modeling conditions and basic data for the study of this dis...

2023-06-13

[Animal modeling] - Study on the mechanism of intermittent fasting in improving the metabolic disorder induced by Olanzapine in mice

To explore the protective effect of intermittent fasting on metabolic disorder induced by Olanzapine in mice and its mechanism...

2023-06-12

【 Animal modeling 】 - Renal in situ inhibition of miR-146b-5p expression improves renal fibrosis in UUO mice

To investigate the expression of miR-146b-5p in a mouse renal fibrosis model and investigate the effect of knocking down miR-146b-5p in vivo on renal injury and fibrosis in mice...

2023-06-12

Experimental Study on Promoting the Repair of Spinal Cord Injury in Rats with MSST1/2 Inhibitors in Animal Modeling

To investigate the effects of MST1/2 inhibitors on the expression of Yes related protein YAP, nerve growth related protein 43, glial fibrillary protein GFAP, apoptosis factor Caspase3, and motor function recovery after spinal cord injury in rats...

2023-06-12

【 Animal Modeling 】 - Lingzhu Tusi Pill Inhibits IKK β/ NF- κ B/MCP-1 pathway reduces adriamycin induced renal Proteinuria in rats

To explore the effect and mechanism of Lingzhu Cusi Pill on adriamycin Nephrin...

2023-06-12

【Animal Modeling】-Establishment and discussion of the body condition evaluation system of rhesus monkeys

In order to know the health status of artificially caged macaques in a timely manner, quickly find out the problems in feeding and management, and provide reasonable feeding and management plans for the artificially-bred macaque units, and initially...

2023-06-12

[Animal experiment]-Vaccine targeting RBP-4 reduces blood sugar in type 2 diabetic mice

Explore the effectiveness and feasibility of vaccine immune intervention with human-derived RBP-4 as the target of insulin resistance, and provide basic research data for the further development of new therapies for type 2 diabetes...

2023-06-12