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To evaluate the cardiotoxicity of the drug sibutramine using two cardiac-specific CYP2E1 gene-modified mice, and to select an animal model with higher sensitivity in evaluating the cardiotoxicity of the drug...
2023-06-27To investigate the effects of intermedin and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia...
2023-06-26To initially establish a rat xenograft model of human glioma by using immunosuppressive agents to provide an ideal experimental tool for clinical and basic research...
2023-06-26To investigate whether CD4+ T cells have the ability to secrete exosomes, and the possibility of CD4+ T cell exosomes participating in inflammation and tumor immune processes...
2023-06-25By blocking the bile duct or injecting sclerosing agent, the extrahepatic bile duct is artificially blocked, causing the bile duct to expand above the blocked site, cholestasis, and increasing the pressure of the bile duct. I will. Intrahepatic blood...
2023-06-25To observe the estrous cycle of NOD/SCID mice and the changes of vaginal smear after ovariectomy...
2023-06-25To use the method of chronic unpredictable moderate stress combined with rapid and chronic modified multi-platform water environment sleep deprivation to replicate the depression and insomnia rat model, compare the two modeling methods, and choose th...
2023-06-25To observe the effects of plantar shock stress duration on the elevated plus maze and anxiety-like behaviors in the opening test in rats...
2023-06-25After the C.trachomatis MoPn Nigg Ⅱ strain was cultured and proliferated on HeLa-229 cells, the infected monolayers were harvested, ultrasonicated for 30 seconds, and centrifuged at 4°C at 500×g for 10 minutes to collect the supernatant. The supernat...
2023-06-25To explore the optimal breeding method and identification method of vitamin D receptor (VDR) knockout mice, and to provide animal models for further study of VDR function and related diseases...
2023-06-21
Myopia, especially high myopia, is associated with major eye diseases that ultimately lead to blindness, such as exudative myopic macular degeneration, rhegmatogenous retinal detachment, myopic retinopathy, and glaucoma. The mechanism of myopia is no...
2023-06-21To establish a humanized mouse model of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) gene, and to provide an effective mouse model for the development and screening of tumor therapeutic antibodies targeting CTLA4...
2023-06-21To investigate the inhibition of proliferation and induction of apoptosis of human colon cancer HT29 cells by deoxyvioletine and its possible mechanism...
2023-06-21To study the pathological characteristics of giant spontaneous tumors in Wistar and GK rats...
2023-06-21To study the protective effect of curcumin on renal fibrosis in chronic kidney disease, and to explore the possible mechanism of action...
2023-06-21To investigate the changes and significance of malondialdehyde, superoxide dismutase and interleukin-6 in lung tissue of acute hypoxia-induced acute pulmonary edema in rats...
2023-06-20