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【Animal Modeling】-Comparative study of hepatotoxicity between matrine and oxymatrine in vitro and in vivo models

【Animal Modeling】-Comparative study of hepatotoxicity between matrine and oxymatrine in vitro and in vivo models

To compare the hepatotoxicity of matrine and oxymatrine, to explore the severity and characteristics of their toxicity, and to preliminarily clarify the toxicity mechanism?...

2023-06-05
【Animal Modeling】-Effect and mechanism of fine particulate matter PM2.5 on atherosclerosis in ApoE knockout mice

【Animal Modeling】-Effect and mechanism of fine particulate matter PM2.5 on atherosclerosis in ApoE knockout mice

The purpose of this experiment was to investigate the effect and mechanism of fine particulate matter PM2.5 on ApoE knockout (Apoe-/-) mice (atherosclerosis model mice)...

2023-06-02
【Animal modeling】-The protective effect of Danggui Buxue decoction on radiation-injured mice

【Animal modeling】-The protective effect of Danggui Buxue decoction on radiation-injured mice

To observe the protective effect of Danggui Buxue Decoction on mice irradiated by 60C0-γ ray...

2023-06-02
【Animal modeling】-Establishment of a rat model of lumbar ventral nerve root traction

【Animal modeling】-Establishment of a rat model of lumbar ventral nerve root traction

To study the pathogenic mechanism and drug development of amyotrophic lateral sclerosis, establish a rat model of pulling the fourth lumbar ventral nerve root, and use brain-derived neurotrophic factor as a positive drug to verify the effectiveness o...

2023-06-02
【Animal Modeling】-Human lung adenocarcinoma transplantation model in different parts of nude mice

【Animal Modeling】-Human lung adenocarcinoma transplantation model in different parts of nude mice

After human tumors are implanted subcutaneously, tumor cells are not easy to invade surrounding tissues, because envelopes are often formed around the graft, and the same tumor cells are not easy to penetrate into the abdominal cavity or other tissue...

2023-06-01
【Animal modeling】-Observation of lifespan of presenilin-1/presenilin-2 double knockout mice

【Animal modeling】-Observation of lifespan of presenilin-1/presenilin-2 double knockout mice

To observe the survival curve of Presenilin-1/Presenilin-2 double knockout mice (dKO mice), and to provide a reference for further reproduction and the use of this model for the study of Alzheimer\\\'s disease (AD)...

2023-06-01
【Animal modeling】-Isolation and culture of mouse spleen mesenchymal stem cells by tissue block method

【Animal modeling】-Isolation and culture of mouse spleen mesenchymal stem cells by tissue block method

To establish an efficient and reliable strategy for the isolation and expansion of mouse spleen mesenchymal stem cells by tissue block culture method...

2023-06-01
【Animal modeling】-Gastroesophageal reflux model

【Animal modeling】-Gastroesophageal reflux model

Gastroesophageal reflux refers to the reflux of gastric contents (such as bile salts and pancreatin) that flows from the duodenum into the stomach and enters the esophagus. It is divided into physiological reflux and pathological reflux...

2023-06-01
【Animal Modeling】-Using monocrotaline to replicate the rat pulmonary hypertension model

【Animal Modeling】-Using monocrotaline to replicate the rat pulmonary hypertension model

Monocrotaline (MCT) is a plant extract of the genus Crotalaria. It is a double-layer pyrrolidine alkaloid that can carbonize the DNA of cancer cells and exert anti-cancer effects, mainly after injection in the body...

2023-06-01
【Animal modeling】-Losartan reduces ventilator-related lung injury in mice and inhibits the expression of caveolin-1 and NOX4 in lung tissue

【Animal modeling】-Losartan reduces ventilator-related lung injury in mice and inhibits the expression of caveolin-1 and NOX4 in lung tissue

To establish a mouse model of mechanical lung injury by ventilator hyperventilation, intervene with angiotensin II receptor inhibitor losartan, and explore the effect of losartan on caveolin-1 in the lung of mice with mechanically ventilated lung inj...

2023-05-31
【Animal modeling】-Experimental study on growth and reproduction of Tlr4 knockout mice

【Animal modeling】-Experimental study on growth and reproduction of Tlr4 knockout mice

To study the similarities and differences in growth and reproduction between Tlr4 knockout mice and KM mice...

2023-05-31
【Animal Modeling】-The effect of four commonly used experimental anesthetics on the cardiovascular system of rats

【Animal Modeling】-The effect of four commonly used experimental anesthetics on the cardiovascular system of rats

Explore the effects of anesthetics in different animal experiments on the cardiovascular system of rats...

2023-05-31
【Animal Modeling】-The effect of self-made Gehua Jiejiu Dizhi Decoction on liver fat deposition and PXR expression in alcoholic fatty liver mice

【Animal Modeling】-The effect of self-made Gehua Jiejiu Dizhi Decoction on liver fat deposition and PXR expression in alcoholic fatty liver mice

Understand the effect of Gehua Jiejiu Dizhi Decoction on liver fat deposition in alcoholic fatty liver (AFLD) mice, and observe its effect on liver tissue pregnane receptor (PXR) and its regulatory target genes CYP3A11 and CYP3A25 proteins...

2023-05-31
【Animal Modeling】-Fluorescence two-dimensional electrophoresis to detect the differences in liver tissue proteomics between male and female mice

【Animal Modeling】-Fluorescence two-dimensional electrophoresis to detect the differences in liver tissue proteomics between male and female mice

To detect the differences in the expression of proteomes in the liver tissue of male and female mice, and to explore the mechanism of gender differences in the occurrence of liver diseases...

2023-05-31
【Animal Modeling】-Analysis of Bacterial Community Diversity in Large Intestine Contents of Tree Shrews

【Animal Modeling】-Analysis of Bacterial Community Diversity in Large Intestine Contents of Tree Shrews

To analyze the structure and composition of E. coli bacteria in tree shrew by high-throughput sequencing technology...

2023-05-30
【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

To investigate the relationship between the protective effect of propofol on cerebral ischemia-reperfusion injury and gap junctions and its possible mechanism...

2023-05-30