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![[Animal modeling drug efficacy evaluation] - Ethanol gavage plus high-fat feeding model](/./uploads/images/default/default.png)
Adult rats were fed a high-fat diet (supplemented with 1% cholesterol and 5% lard on top of a low-fat diet) for one week after normal feeding. At the same time, they were orally administered with 1.5ml/kg body weight of 60% ethanol twice a day for 12...
2024-09-02All animals were weighed before the experiment and deprived of water for 24 hours. Those who lost more than 10% of their body weight entered the experiment and were randomly divided into two groups: the model group [acute renal failure (ARF) group]: ...
2024-09-02Lysine antagonism is the earliest animal model established for antidepressant research after the discovery that monoamine oxidase inhibitors and tricyclic antidepressants can counteract the abnormal behavior caused by Lysine. It is commonly used for ...
2024-08-30Due to their susceptibility to dermatophytosis, guinea pigs often develop spontaneous dermatophytosis, making them an ideal animal model for studying dermatophytosis; In addition, there have also been reports of a rabbit model of dermatophyton...
2024-08-30Animal: Male SD rats, weighing 180-250g; Medication: 50% glycerol...
2024-08-3015% egg yolk powder, 0.5% cholesterol, 5% lard, 79.5% basic feed, fed for 6 weeks to form a mold...
2024-08-29Rapid atrial stimulation has various effects on the electrical activity of atrial cells, such as shortening the effective refractory period (AERP) of the atrium, increasing the heterogeneity (non-uniformity or dispersion) of AERP, and slowing down lo...
2024-08-29On the 7th and 14th day after removing one kidney, animals were injected twice with 5mg/kg of daunorubicin via tail vein...
2024-08-29Spinal cord compression is one of the important causes of spinal cord injury. This injury model mainly simulates spinal cord injury caused by space occupying lesions in the spinal canal, which can be divided into acute compression injury and chronic ...
2024-08-28The principle of platform sleep deprivation is to utilize the living habits of rats, which are afraid of water and unable to enter sleep in water. By placing a platform in a water tank, the rats can stand on the platform. Due to the small diameter of...
2024-08-28Intramuscular injection of 12mg/kg mercuric chloride solution into modeling animals...
2024-08-28Before the experiment, create a ureteral fistula or bladder fistula in the dog, and inject a 2% mercuric solution subcutaneously into the abdomen of the model animal at a dose of 20mg/kg...
2024-08-28Dissolve egg protein in physiological saline to prepare a 20g/L solution, and then mix it thoroughly with an equal amount of Freund\'s adjuvant. Subcutaneous injection of animal back, once a week, for 3 consecutive weeks to induce sensitization. Two ...
2024-08-27Adjuvant arthritis (AA), also known as Freund\'s adjuvant arthritis, was founded by bacteriologist Freund in the 1950s and is the basic method for animal models of immune arthritis...
2024-08-27Female experimental rats were anesthetized by intraperitoneal injection of 2% pentobarbital sodium at a dose of 40mg/kg body weight. A sterile midline incision was made in the lower abdomen, and the abdominal muscles were bluntly separated from the p...
2024-08-27Select female rats weighing 70-100g after weaning, prepare different concentrations of sodium fluoride solution for poisoning with distilled water, and calculate the poisoning volume based on 0.5ml/100g body weight...
2024-08-27