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![[Animal modeling drug efficacy evaluation] - replication of disseminated intravascular coagulation model using rabbit brain powder infusion](/./uploads/images/default/default.png)
Preparation of rabbit brain powder infusion: euthanize the rabbit by bloodletting, remove the rabbit brain, clean the attached blood vessels and meninges, rinse it clean, and then use gauze to absorb it. Place it in a mortar and add acetone. Grind ...
2024-09-05rats, weighing 220-250g; Drug: Oleic acid...
2024-09-05Healthy adult male SD rats, weighing 180-220g; Medication: 10% chloral hydrate, FeCl2 solution...
2024-09-05To design and establish a rat liver fibrosis model with bile duct ligation and recanalization, and to observe the effects of bile duct ligation and recanalization on epithelial-mesenchymal phenotype and oxidative stress-related protein expression in...
2024-09-05The delayed response test based on the Wisconsin Universal Tester is a common method to evaluate the learning and memory ability of non-human primates. The experiment is affected by many factors during the process. The learning and memory ability has...
2024-09-05Vazquez Lopez first discovered that viruses can induce tumors, but the pathogenesis has not been fully elucidated...
2024-09-04The acute epilepsy model is often a one-time acute seizure model that can induce epilepsy with a single treatment. Including the maximum electroconvulsive epilepsy model and the pentylenetetrazole epilepsy model...
2024-09-04The occurrence of lymphoma is a multifactorial and multi-stage process. Various mechanisms such as cell cycle regulation, abnormal anti apoptotic pathways, and tumor suppressor pathways play important roles in the pathogenesis of lymphoma...
2024-09-04Bcr/bl transgenic mouse model: Through cloning and analysis of the promoter sequence and function of the mouse Tec gene, it was found that genes regulated by the Tec promoter are only specifically expressed in the cytoplasm of hematopoietic stem cell...
2024-09-04male domestic dogs, weighing 10-20kg; Medication; Pentobarbital, norepinephrine...
2024-09-04The most commonly used inducer is N-methylnitrosourea (MNU). Its carcinogenic mechanism is related to the formation of O6 methylguanine, which causes GyA point mutations during DNA replication...
2024-09-03Inducing retinal diseases through medication or physical methods to alter the structure of the retina, resulting in conditions similar to human retinitis pigmentosa...
2024-09-03Knocking out genes related to retinal diseases to obtain animal models with stable clinical phenotypes and clear genetic backgrounds provides an important research tool for studying the functions of related genes and their encoded proteins...
2024-09-03Dry eye disease, also known as dry keratoconjunctivitis, is one of the most common eye diseases, which can cause damage to the ocular surface and blurred vision, affecting the quality of life of patients...
2024-09-03NOD mice are the best model for studying human type 1 diabetes, and they are very similar to human in genetics and immunity. The main susceptibility gene of human type 1 diabetes is located in MHC, and the susceptibility gene of NOD mice is also loca...
2024-09-03Injecting some chemical carcinogens into different parts of animals in different ways can induce tumors, but the incidence, type, and location of tumors induced by carcinogens vary depending on their dosage, animal age, strain, and physiological stat...
2024-09-03