动物造模,药效评价,肾病 z-bio 2024-08-28 382

　　1. Modeling material animals: rats, weighing 190-250g; Drug: mercuric chloride.

　　2. Modeling method: Inject 12mg/kg mercuric chloride solution intramuscularly into the animal model.

　　3. Modeling principle: Mercury poisoning causes kidney disease in rats.

　　4. Changes after modeling: Within 24 hours after modeling, animal kidney function is impaired, glomerular filtration rate progressively decreases, water reabsorption by the proximal tubules also decreases, tubular pressure decreases, urine output can be less than 3ml/24h, and urine osmolarity is less than 610mOsm/L.