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[Animal Modeling Drug Efficacy Evaluation ]- Duodenal Reflux Surgery Induced Chronic Gastric Ulcer Animal Model

[Animal Modeling Drug Efficacy Evaluation ]- Duodenal Reflux Surgery Induced Chronic Gastric Ulcer Animal Model

Adult rats were fasted without water for 24 hours, anesthetized with pentobarbital sodium, and placed in a supine position with a midline incision. The lateral wall of the jejunum, 10cm away from the Treitz ligament, was anastomosed with the anterior...

2024-08-26
[Animal modeling drug efficacy evaluation] - HP induced chronic gastric ulcer animal model

[Animal modeling drug efficacy evaluation] - HP induced chronic gastric ulcer animal model

  BALB/c mice, SPF grade, 5-7 weeks old, fasted for 12 hours, anesthetized and opened the abdomen. At the posterior wall of the greater curvature of the stomach, a No. 2 surgical cotton thread containing corrosive drugs (soaked in a solution of 15% c...

2024-08-26
[Animal Modeling - Pharmacological Evaluation] - Chemical Induced Acute Gastric Ulcer Animal Model

[Animal Modeling - Pharmacological Evaluation] - Chemical Induced Acute Gastric Ulcer Animal Model

Adult experimental mice were fasted and kept in water for 48 hours. They were orally gavaged with anhydrous ethanol (5ml/kg body weight dose), acetylsalicylic acid (200mg/kg body weight dose), or 0.6mol/L hydrochloric acid (10ml/kg body weight dose)....

2024-08-26
[Animal Modeling - Pharmacological Evaluation] - Gastrointestinal Anastomosis Induced Chronic Atrophic Gastritis Animal Model

[Animal Modeling - Pharmacological Evaluation] - Gastrointestinal Anastomosis Induced Chronic Atrophic Gastritis Animal Model

Adult rats were fasted without water for 18 hours, and then anesthetized with pentobarbital sodium at a dose of 30mg/kg body weight. The stomach and jejunum were exposed, and the anterior stomach about 2cm away from the pylorus and the jejunum 5-7cm ...

2024-08-26
[Animal Modeling - Pharmacological Evaluation] - Acute Gastritis Animal Model

[Animal Modeling - Pharmacological Evaluation] - Acute Gastritis Animal Model

Adult male rats were fasted without water for 48 hours, orally administered with 100mg/kg body weight of acetylsalicylic acid, or 10mmol/L acetic acid or different concentrations of hydrochloric acid (1, 10, 10mmol/L), or administered with the same b...

2024-08-26
[Animal modeling - Drug efficacy evaluation] - Acid infusion method for reflux esophagitis model

[Animal modeling - Drug efficacy evaluation] - Acid infusion method for reflux esophagitis model

Apply adult rabbits weighing 2-3kg. Rabbits were fasted for 12 hours before surgery but were unable to drink water...

2024-08-26
[Animal Modeling Drug Efficacy Evaluation] - Esophageal Varicose Vein Model of Canine Portal Hypertension

[Animal Modeling Drug Efficacy Evaluation] - Esophageal Varicose Vein Model of Canine Portal Hypertension

Adult Beagle dogs were fasted 16 days before surgery and anesthetized with 10mg/kg body weight of ketamine via intramuscular injection. The animals were then placed on the operating table for fixation...

2024-08-26
[Animal Modeling Drug Efficacy Evaluation] - Esophageal Narrowing Animal Model

[Animal Modeling Drug Efficacy Evaluation] - Esophageal Narrowing Animal Model

Adult Beagle dogs weighing 8-14kg were anesthetized by intravenous injection of pentobarbital sodium at a dose of 30mg/kg body weight. The dogs were then fixed on their side on the operating table, and the neck surgical area was routinely disinfected...

2024-08-26
[Animal Modeling - Efficacy Evaluation] - Extracorporeal Circulation Animal Model

[Animal Modeling - Efficacy Evaluation] - Extracorporeal Circulation Animal Model

  Rats were anesthetized by intraperitoneal injection of pentobarbital sodium at a dose of 30mg/kg body weight, followed by oral intubation and mechanical ventilation (frequency 60 times/min, peak airway pressure 9.0cmH2O (0.88kPa)). Left femoral art...

2024-08-26
[Animal Modeling - Pharmacological Evaluation] - Portal Hypertension Esophageal Varicocele Animal Model

[Animal Modeling - Pharmacological Evaluation] - Portal Hypertension Esophageal Varicocele Animal Model

After fasting and water deprivation for 8 hours, rats were anesthetized using conventional methods and fixed in a supine position on the operating table. The skin was cut 2.5-3.0cm in the center of the abdomen, and the abdominal cavity was opened alo...

2024-08-26
[Animal Modeling - Pharmacological Evaluation] - Saffron Red O-induced Kidney Disease Model in Rabbits

[Animal Modeling - Pharmacological Evaluation] - Saffron Red O-induced Kidney Disease Model in Rabbits

rabbits, weighing 2-3kg; Medication: Saffron Red O, Renluo Liquid...

2024-08-26
[Animal modeling - Drug efficacy evaluation] - Purimycin induced nephropathy model

[Animal modeling - Drug efficacy evaluation] - Purimycin induced nephropathy model

Healthy male rats weighing 100-150g; Drug: Puromycin...

2024-08-26
【Animal Modeling - Pharmacological Evaluation】 - Lead induced Nephropathy Animal Model

【Animal Modeling - Pharmacological Evaluation】 - Lead induced Nephropathy Animal Model

Healthy male SD rats, weighing (220 ± 20) g; Drug: Lead acetate...

2024-08-26
[Animal Modeling - Pharmacological Evaluation ]- Chemical induced Pulmonary Edema Animal Model

[Animal Modeling - Pharmacological Evaluation ]- Chemical induced Pulmonary Edema Animal Model

Adult New Zealand rabbits weighing over 2kg were anesthetized with pentobarbital sodium injected intraperitoneally at a dose of 30mg/kg body weight, and then placed supine with their head and limbs fixed on the operating table. Neck hair removal, rou...

2024-08-22
[Animal Modeling - Pharmacological Evaluation] - Respiratory Distress Syndrome Animal Model

[Animal Modeling - Pharmacological Evaluation] - Respiratory Distress Syndrome Animal Model

Administer a dose of 120mg/kg body weight to experimental rats by gavage, diluted with physiological saline to 20mg/L paraquat...

2024-08-22
[Animal Modeling - Pharmacological Evaluation] - Bronchiectasis Animal Model

[Animal Modeling - Pharmacological Evaluation] - Bronchiectasis Animal Model

SD rats weighing around 200g and around 4 months old were anesthetized by intraperitoneal injection of pentobarbital sodium at a dose of 30mg/kg body weight. The animal is fixed in a supine position on the surgical plate. After routine disinfection a...

2024-08-22