[Animal modeling]- doxorubicin induced cardiomyopathy model

Doxorubicin is a commonly used cycle non-specific anti-tumor chemotherapy drug in clinical practice. While anti-tumor, it also forms superoxide free radicals, destroys cell membrane structure and function. Its mechanism of myocardial toxicity is to p...

2024-02-18

[Animal Modeling] - Electrical Stimulation Induced Ventricular Arrhythmia Model

Electrical stimulation can change the membrane conductivity of myocardial cells, increase the heterogeneity of myocardial repolarization, and make the stimulation more prone to fibrillation during the vulnerable period. The ventricular fibrillation t...

2024-02-18

[Animal Modeling] - Acute Myocardial Ischemia and Atrial Fibrillation Model

Acute ischemia delays the conduction of impulses in the ischemic area of the atrium, making it easier for reentry to form and leading to the occurrence of atrial fibrillation...

2024-02-18

【Animal Modeling】-Influence of inflammatory factor storm on immune response to infection in aged mice

After highly pathogenic avian influenza-infected mice, over-expressed inflammatory factors, known as inflammatory factor storm, were detected in the lungs....

2024-02-18

[Animal Modeling] - Homologous Immune Liver Injury Model

Healthy adult guinea pigs, weighing 250-400g, regardless of gender; Medication: Freund\'s complete adjuvant; Instrument: homogenizer...

2024-02-18

[Animal Modeling] - Heterologous Immune Liver Injury Model

hybrid rats or mice, newly weaned male purebred mice; Medication: Freund\'s complete adjuvant; Equipment: High speed freezer centrifuge, homogenizer...

2024-02-18

[Animal modeling] - carbon tetrachloride induced rabbit liver cirrhosis model

Healthy 3-month-old New Zealand white rabbits, weighing (1.8 ± 0.2) kg; Medications: Full price nutritional pellet rabbit feed, CCl4, olive oil, edible ethanol...

2024-02-18

[Animal Modeling] - Carbon Tetrachloride Cirrhosis Animal Model

Wistar or SD rats, weighing around 180-200g; Medication: 40% to 50% carbon tetrachloride oil solution, 20% to 30% alcohol, pure corn flour (mixed with 0.5% cholesterol)...

2024-02-18

[Animal Modeling] - Macaque Liver Fibrosis Model

macaques, male, aged 7-10 years old, weighing 8-10kg; Drug: Analytical pure CCl4...

2024-02-18

[Animal modeling] - Pingyangmycin iodine oil emulsion induced liver fibrosis model

Animal: 4-5 month old Japanese white rabbits with large ears, regardless of gender, weighing (2.5 ± 0.2) kg; Medication: Pingyangmycin iodine oil emulsion...

2024-02-18

[Animal modeling] - Animal model of radiation injury with blood stasis syndrome

Adult mice were placed in a 60Co organic glass light box γ Radiation source illumination, height 80cm, whole body illumination of 6.0Gy, dose rate of 1.15Gy/min. Three days after irradiation, the mouse was euthanized due to cervical dislocation. The ...

2024-02-18

【Animal modeling】-Effect of lamotrigine on the expression of PGP, MVP and amino acid content in the hippocampus of chronic epilepsy rats

To investigate the effect of lamotrigine on the expression and amino acid content of P-glycoprotein and main vault protein in the hippocampus of chronic epilepsy rats...

2024-02-18

【Animal Modeling】-The effect and mechanism of betel nut on the antidepressant effect in mice

To study the effect of betel nut on depressive-like behavior in mice and its mechanism...

2024-02-18

[Animal modeling] - Shionone improves the immune response and TLRs expression of OVA induced asthmatic SD young rats

To study the effects of shionone on the expression of Toll like receptor and immune response in ovalbumin induced asthmatic SD rats...

2024-02-18

【Animal Modeling】-A new method and evaluation for the establishment of a rabbit carotid atherosclerotic plaque model

To explore a new method for establishing a rabbit common carotid atherosclerosis model by using balloon-injured common carotid artery intima and feeding with high-fat diet through the central artery of rabbit ear, and to evaluate the feasibility...

2024-02-18

【Animal Modeling】-Visual assessment of microcirculation after acute myocardial infarction in rabbits by contrast echocardiography

Evaluation of blood perfusion in infarcted segments after acute myocardial infarction using contrast-enhanced echocardiography in a rabbit model of acute myocardial infarction...

2024-02-18