动物造模 zi-bio 2024-02-18 816

　　(1) Reproduction method: Adult mice were placed in a 60Co organic glass light box γ Radiation source illumination, height 80cm, whole body illumination of 6.0Gy, dose rate of 1.15Gy/min. Three days after irradiation, the mouse was euthanized due to cervical dislocation. The left femur was taken, fixed, embedded, sliced, and stained. The number and area of bone marrow microvascular roots and the percentage change of bone marrow hematopoietic tissue capacity were observed under high magnification microscopy.

　　(2) Model characteristics: The number and area of microvessels in model animals significantly decreased, and the percentage of hematopoietic tissue volume significantly decreased.

　　(3) The bone marrow microcirculation system in comparative medicine is highly sensitive to ionizing radiation, mainly manifested as sinus dilation, congestion, increased permeability, bleeding, and a sharp decrease in hematopoietic cells. This change is also a manifestation of congestion syndrome. Based on the comprehensive analysis of the appearance and other biological information of the radiation-induced model mice, it was found that radiation damage not only presents with blood stasis syndrome, but also has characteristics such as qi deficiency syndrome.