[Animal Modeling - Pharmacological Evaluation] - Stress Induced Duodenal Ulcer Animal Model

Adult rats were fasted without water for 16 hours, anesthetized with intraperitoneal injection of pentobarbital sodium, and fixed. Then, an electric pusher was used to push the hair on the area slightly larger than the intended burn area. Dip a gauze...

2024-08-21

[Animal modeling - Drug efficacy evaluation] - Hot water scald induced stress-induced gastric ulcer animal model

Adult experimental rats were fasted and deprived of water for 24 hours. They were anesthetized by intraperitoneal injection of pentobarbital sodium at a dose of 30mg/kg body weight. The animals were immersed in a hot water tank at 80-92 ℃ for 10-18 s...

2024-08-21

[Animal modeling - Drug efficacy evaluation] - Water immersion restraint method induced stress-induced gastric ulcer animal model

Adult rats were fasted without water for 24 hours, anesthetized with ether, and placed in a supine position. The animal\'s limbs and neck were tied and fixed onto a mouse plate...

2024-08-21

[Animal modeling drug efficacy evaluation] - HP induced chronic atrophic gastritis animal model

Mouse model: BALB/c mice, SPF grade, 6-8 weeks old. After fasting for 12 hours and water deprivation for 8 hours, inoculate Hp (SS1) culture suspension at 1000000000000 CFU/L once every other day, for a total of 3 times, with 100 μ l per time. Prepar...

2024-08-21

[Animal Modeling - Pharmacological Evaluation] - Physical Factors Induced Chronic Atrophic Gastritis Animal Model

Adult rats were orally administered with a 55 ℃ 15% sodium chloride (NaCl) solution or simply 10ml/kg body weight of 55 ℃ distilled water once daily for 12-32 weeks. During this period, the general activity of the animals was continuously observed. A...

2024-08-21

【Animal Modeling - Pharmacological Evaluation 】- Acute Gastritis Animal Model

Adult male rats were fasted without water for 48 hours, orally administered with 100mg/kg body weight of acetylsalicylic acid, or 10mmol/L acetic acid or different concentrations of hydrochloric acid (1, 10, 10mmol/L), or administered with the same b...

2024-08-21

[Animal modeling - efficacy evaluation] - Genetic engineering atherosclerosis model

　　6-8 week old ApoE gene deficient mice (strain C57BL/6J), half male and half female, weighing 18-20g, were fed with a \"Western type diet\" feed containing 21% fat and 0.15% cholesterol (treated with 60CO sterilization and irradiation). Th...

2024-08-21

[Animal modeling - efficacy evaluation] - Atherosclerosis model of hypothalamic arcuate nucleus lesion

Newborn Wistar rats were subcutaneously injected with 10% monosodium glutamate at a dose of 4g/kg body weight on the 1st, 3rd, 5th, 7th, and 9th days after birth, for a total of 5 injections...

2024-08-21

[Animal modeling - Drug efficacy evaluation] - Hypertension model induced by medullary nerve compression

After routine anesthesia in adult experimental dogs, tracheal intubation was performed, and a right femoral artery intubation was performed. A multi-channel physiological recorder was connected to monitor blood pressure...

2024-08-21

[Animal modeling - efficacy evaluation] - quail atherosclerosis animal model

Male quail weighing 90-110g and aged 5-6 weeks...

2024-08-21

[Animal modeling - Drug efficacy evaluation] - Extrarenal bandaging induced hypertension model

Also known as extrarenal compression hypertension model, it can be divided into two kidney one bundle type (one kidney bundle, bilateral kidney preservation), one kidney one bundle type (one kidney bundle, contralateral kidney resection), and two kid...

2024-08-21

[Animal Modeling - Pharmacological Evaluation] - Rabbit Hemorrhagic Disease Virus Induced DIC Animal Model

Take HI negative young rabbits weighing 1.5-2.5kg. Each rabbit was intraperitoneally injected with 2ml of 1:10 hepatotoxicity (hemorrhagic virulent FII strain), and their body temperature was measured every 6 hours before and after infection...

2024-08-21

[Animal Modeling - Pharmacological Evaluation] - Escherichia coli endotoxin induced rabbit DIC model

Male New Zealand rabbits weighing around 2kg were injected with 250 μ g of pathogenic Escherichia coli endotoxin through the ear vein...

2024-08-21

【Animal modeling - Drug efficacy evaluation】 - Thrombosis formation in rabbit aorta after intubation injury

The experimental rabbits were fixed after routine anesthesia. Take a polyethylene tube (diameter 0.5-0.7mm) and insert it from the right femoral artery to the aorta. After 4 hours, insert another polyethylene tube into the left carotid artery and was...

2024-08-21

[Animal Modeling - Efficacy Evaluation] - Small Animal Infection Model

The guinea pigs, albino hamsters, black line hamsters, rats, Brandt\'s voles and chickens were infected with 10 5.7 power TCID50/ml SARS-CoV BJ201 strain by nasal drip. The infection doses were 0.5 ml for guinea pigs, 0.2 ml for albino hamsters, 0.2 ...

2024-08-21

[Animal Modeling - Efficacy Evaluation] - SARS Infection Models in Crab eating Monkeys and Rhesus Monkeys

Healthy rhesus macaques and crab eating macaques aged 3-6 years old were anesthetized by intramuscular injection of Rapid Sleep at a dose of 0.15ml/kg body weight, and then infected with SARS CoV BJ01 strain (10 ^ 5.7 TCID50/ml) through nasal and tra...

2024-08-21