动物造模,药效评价,呼吸窘迫综合征 z-bio 2024-08-22 518

　　(1) The model was made by orally administering a dose of 120mg/kg body weight to experimental rats, diluted with physiological saline to 20mg/L of paraquat.

　　(2) After 4 days of drug administration, under light microscopy, it was observed that the inflamed lung tissue partially shrank and formed a blind cavity, losing the function of alveolar ventilation. The exudate of inflammatory substances formed a protein transparent membrane on the inner surface of the alveoli. After FITC staining, laser scanning confocal microscopy observation showed a complete layer of green fluorescence on the entire alveolar endometrium.

　　(3) Comparative medical significance: Respiratory distress syndrome is a respiratory failure caused by various acute lung injuries, characterized by non cardiogenic pulmonary edema, respiratory distress, and hypoxemia, with an acute onset and high mortality rate. The characteristic pathological process of respiratory distress syndrome is the formation of a protein transparent membrane in the alveoli. Studies on rat models have shown that this transparent membrane contains at least a large amount of IgM and IgG.