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![[Animal Modeling - Pharmacological Evaluation] - Transgenic Animal Model of Bronchial Asthma](/./uploads/images/default/default.png)
Mainly using transgenic or gene knockout technology to study the role of changes in certain gene expression products in the development of asthma...
2024-08-22Anesthetize adult healthy dogs by intraperitoneal injection of pentobarbital sodium at a dose of 40mg/kg body weight; After anesthesia, the animal is fixed supine on the surgical plate, and the abdominal surgical area is routinely disinfected. The ab...
2024-08-22Use male adult rats weighing 250-270g. Abdominal infection group underwent intestinal fistula surgery: Rats were fasted for 8 hours before surgery, anesthetized with ketamine injected intraperitoneally at a dose of 100mg/kg body weight, and then fixe...
2024-08-22BALB/c mice weighing 21-25g (rats weighing around 200g can also be used), regardless of gender. Animals were raised adaptively for one week and fasted for 12 hours before the experiment. After intraperitoneal injection of pentobarbital sodium anesthe...
2024-08-22Male KM mice weighing 18-22g were anesthetized by intraperitoneal injection of pentobarbital sodium at a dose of 30mg/kg body weight. After anesthesia, the animals were fixed in a supine position on a surgical plate, and the abdominal surgical area w...
2024-08-22Rabbit, male or female, weighing 2-3kg, with haircuts, disinfected cloth, and 3-4 incisions made in the middle of the abdomen under the xiphoid process to expose and separate the common bile duct. A sterile plastic tube with a diameter of 1mm was pla...
2024-08-22Guinea pigs weighing 300-400g were anesthetized with ether, and the abdominal cavity was opened to expose the gallbladder. After suctioning out the bile with a 1ml syringe, 3 × 10000 Escherichia coli, or a filtered 20% fresh suspension of guinea pig ...
2024-08-22Adult animals, anesthetized and fixed, open the abdomen along the midline, and perform a purse string suture on the inferior vena cava above the renal vein using 5-0 vascular suture thread. After finding the portal vein from the root of the mesentery...
2024-08-22Adult rats were anesthetized by intraperitoneal injection of ether or ketamine at a dose of 100mg/kg body weight, fixed in a supine position, and opened along a transverse incision in the upper abdomen. The abdominal wall blood vessels were cauterize...
2024-08-22Adult rats were anesthetized and underwent laparotomy through a midline incision on the navel. The common bile duct was sutured with 7-0 silk thread 1cm from the porta hepatis. After the surgery, regular feeding for 2-8 weeks. During this period, pay...
2024-08-22Adult male rats were intraperitoneally injected with 0.5% dimethylnitrosamine (DMNA) at a dose of 10mg/kg body weight for 3 consecutive days per week, once a day, for a total of 4 weeks. Alternatively, thioacetamide (TAA) can be intraperitoneally inj...
2024-08-22Adult baboons were fed with Liebert Decarh ethanol liquid feed, which consisted of a formula of 18.6% casein, 0.23% L-cysteine, 0.14% DL methionine, 2.3% corn oil, 7.7% olive oil, 0.72% linoleic acid and ethyl linoleate, 70.3% dextrin and maltose sug...
2024-08-22Male weaned rats were fed 8-10g of low protein high-fat feed lacking choline daily for 2-3 months. This feed is composed of casein or soybean as the protein source, supplemented with sucrose, lard, vitamin powder, salt, and a quantitative amount of L...
2024-08-22Adult male rats were intraperitoneally injected with 2ml/kg body weight of 30% CCl4 paraffin oil solution twice a week for 7 consecutive weeks. Or subcutaneous injection of 3ml/kg body weight of 40% CCL4 soybean oil solution, with the first dose of 5...
2024-08-22Adult rats were anesthetized and their abdominal cavity was opened to locate and free the common bile duct in the mesentery of the descending duodenum. Two silk threads were threaded underneath and a \"V\" - shaped incision was made towards...
2024-08-22Adult SD rats, aged 5-6 months and weighing 250-400g, were implanted with a colon of 3-4cm under the right renal capsule of 14-16-day-old homologous fetal rats. On postoperative days 7, 14, and 21, 5-10ml of cardiac blood was extracted for the separa...
2024-08-21