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【Animal Modeling】-Establishment of a rat model of chronic hyperuricemia with renal damage

【Animal Modeling】-Establishment of a rat model of chronic hyperuricemia with renal damage

To provide a model tool for drug development against chronic hyperuricemia renal damage by establishing a rat model of chronic hyperuricemia renal damage...

2023-03-13
【Animal modeling】-Preliminary study on the myocardial injury model of rhesus monkeys induced by isoproterenol

【Animal modeling】-Preliminary study on the myocardial injury model of rhesus monkeys induced by isoproterenol

To explore the method of using isoproterenol to induce myocardial injury in rhesus monkeys...

2023-03-13
[Animal modeling]-Establishment of real-time fluorescent quantitative PCR method for mouse hepatitis virus and its application in some rodents

[Animal modeling]-Establishment of real-time fluorescent quantitative PCR method for mouse hepatitis virus and its application in some rodents

Establish a real-time fluorescent quantitative PCR method to detect mouse hepatitis virus (MHV), and first use it to detect experimental nude mice and other rodents...

2023-03-13
【Animal modeling】-Experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Jiawei Danshen Decoction in vitro

【Animal modeling】-Experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Jiawei Danshen Decoction in vitro

To investigate the experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Modified Danshen Decoction in vitro...

2023-03-10
【Animal modeling】-Metformin regulates the effect of miR-34a on airway inflammation in COPD rats

【Animal modeling】-Metformin regulates the effect of miR-34a on airway inflammation in COPD rats

To investigate the effect of metformin (Met)-regulated microRNA (miR)-34a on airway inflammation in rats with chronic obstructive pulmonary disease (COPD)...

2023-03-10
【Animal Modeling】-Observation of some physiological indicators of rhesus monkeys using implanted telemetry technology

【Animal Modeling】-Observation of some physiological indicators of rhesus monkeys using implanted telemetry technology

To observe the circadian variation of physiological indicators such as respiration, blood pressure, ECG, and body temperature in awake rhesus monkeys with implanted telemetry technology and changes during stress...

2023-03-10
【Animal modeling】-Protective effect and mechanism of pine bark extract on cerebral ischemia-reperfusion injury in mice

【Animal modeling】-Protective effect and mechanism of pine bark extract on cerebral ischemia-reperfusion injury in mice

To investigate the neurotherapeutic effect and mechanism of IL-6/STAT3/miR-21 in pine bark extract on cerebral ischemia-reperfusion injury in mice...

2023-03-09
【Animal Modeling】-Based on a systematic review of pathomorphology to explore the differences between porcine coronary balloon injury lesions and atherosclerosis

【Animal Modeling】-Based on a systematic review of pathomorphology to explore the differences between porcine coronary balloon injury lesions and atherosclerosis

The histomorphological characteristics of porcine coronary artery balloon injury lesions were analyzed through a systematic review, and compared with the histomorphological characteristics of human atherosclerotic plaques, in order to provide a basis...

2023-03-09
【Animal Modeling】-Effect of continuous multiple application of propofol and vitamin C on anesthesia in mice

【Animal Modeling】-Effect of continuous multiple application of propofol and vitamin C on anesthesia in mice

To investigate the anesthesia effect of propofol or propofol combined with vitamin C on mice for 6 consecutive days...

2023-03-09
【Animal Modeling】-Effect and mechanism of propofol intervention on optic nerve injury in rats

【Animal Modeling】-Effect and mechanism of propofol intervention on optic nerve injury in rats

To investigate the effect and mechanism of propofol intervention on the injured optic nerve and retinal ganglia after optic nerve injury in rats...

2023-03-09
【Animal Modeling】- Establish a humanized mouse model of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) gene, which provides an effective mouse model for the development and screening of tumor the

【Animal Modeling】- Establish a humanized mouse model of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) gene, which provides an effective mouse model for the development and screening of tumor the

To establish an animal model suitable for evaluating the efficacy of traditional Chinese medicine compound and new drug development for ulcerative colitis with damp-heat syndrome, and to explore the difference and relationship between common ulcerati...

2023-03-09
【Animal modeling】-Comparative study on the induction of specific CD8+ T cell immune responses in C57BL/6 mice infected with influenza A virus H1N1pdm09 and PR8

【Animal modeling】-Comparative study on the induction of specific CD8+ T cell immune responses in C57BL/6 mice infected with influenza A virus H1N1pdm09 and PR8

To compare the two subtypes of influenza A virus H1N1 strains A/Shanghai/37T/2009(H1N1)(pdm09) clinical isolates and A/PuertoRico/8/34(H1N1)(PR8) standard strains infected with C57BL/6 small Changes in the pathological state and the induction of immu...

2023-03-09
【Animal modeling】-The improvement effect of treadmill exercise on the motor function of elderly rats

【Animal modeling】-The improvement effect of treadmill exercise on the motor function of elderly rats

To investigate the change rule of rat motor function with increasing age, and the improvement effect of exercise on the motor function of elderly rats....

2023-03-08
【Animal modeling】-Using Matrigel to block the portal vein to establish an improved ALPPS surgery mouse model

【Animal modeling】-Using Matrigel to block the portal vein to establish an improved ALPPS surgery mouse model

To establish a modified two-step hepatectomy mouse model with liver partition and portal vein ligation independent of microsurgical techniques, and to verify its effectiveness in stimulating liver regeneration...

2023-03-08
【Animal modeling】-Optimization of in vivo chromosomal aberration test in ICR mice

【Animal modeling】-Optimization of in vivo chromosomal aberration test in ICR mice

To carry out in vivo chromosomal aberration experiments in ICR mice, by administering cyclophosphamide and colchicine at different time points, to compare the effects of different administration/collection time points and different administration con...

2023-03-08
【Animal Modeling】-Methodological comparative analysis of orthotopic and subcutaneous PDX models of hepatocellular carcinoma

【Animal Modeling】-Methodological comparative analysis of orthotopic and subcutaneous PDX models of hepatocellular carcinoma

To construct orthotopic and subcutaneous human tumor xenograft models of hepatocellular carcinoma, and to compare and analyze the growth and pathological characteristics of the two models...

2023-03-08