[Animal experiment]-The mechanism of transient receptor potential channel C1 in airway remodeling in guinea pig asthma and the intervention effect of budesonide

To explore the mechanism of TRPC1 ion channel in the development of airway remodeling, and to interfere with the intervention of budesonide by blocking the expression of transient receptor potential channel C1 (TRPC1)...

2020-08-22

【Animal experiment】-Effects of bis(2-ethylhexyl) phthalate exposure during pregnancy on growth and development of mouse placenta

The in vivo effects of DEHP exposure on mouse placental growth and development, maternal-fetal interface uNK cell number and angiogenesis through exposure to bis(2-ethylhexyl) phthalate during pregnancy...

2020-08-22

[Animal experiment]-Protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing damage in guinea pigs

Guinea pig cochlear autophagy-related proteins beclin1 and LC3, Na + -K + -2Cl-complex transporter (NKCC1) mRNA, endothelin (ET) expression and cochlear gentamicin (GM) damage and pefentamine hydrochloride The relationship between salt...

2020-08-22

【Animal Experiment】-Ghrelin\'s Effect on Hippocampal DKK-1 Expression and Learning and Memory Function of Diabetic Rats

Observe the expression changes of Ghrelin on DKK-1 and WNT signaling pathways in diabetic rats, and explore the mechanism of its involvement in learning and memory functions...

2020-08-22

[Animal experiment]-Expression and significance of basic leucine zipper transcription factor ATF-like protein in kidney tissue of lupus mice

To explore the expression of leucine zipper gene transcription factor ATF-like protein (basucucinezipper transcription factor, ATF-like, BATF) in the kidney tissue of lupus mice and its clinical significance...

2020-08-22

[Animal experiment]-RNA interference specifically blocks the effect of local angiotensin Ⅱ type 1 receptors on first-phase insulin secretion

Observe the changes in the first phase insulin secretion of pancreatic islets in db/db mice after blocking the expression of local angiotensin II type 1 receptor (AT1R) by RNA interference technology and explore its underlying mechanism...

2020-08-22

【Animal Experiment】-The effect of rapamycin on the proliferation of rat aortic valve interstitial cells

Using rapamycin as a target to inhibit mTOR and study its effect on the proliferation of rat heart valve stromal cells...

2020-08-22

[Animal experiment]-Study on subacute inhalation toxicity of Ivermectin to rats

To study the subacute inhalation toxicity of ivermectin to rats to achieve the maximum unobserved effect level...

2020-08-22

[Animal Experiment]-Study the changes of platelet mitochondria after tourniquet limb ischemia-reperfusion injury

Explore the changes of platelet mitochondria after tourniquet ischemia-reperfusion injury, and provide guidance on the clinical application of hemostasis...

2020-08-22

[Animal experiment]-The effect of apoptosis signal regulatory protein 1 on the expression of GFAP, vimentin and hind limb motor function after spinal cord injury in rats

To explore the expression of apoptotic signal regulatory protein 1 (ASK1) in the glial scar after spinal cord injury (SCI), the expression of its protein, glial fibrillary acidic protein (GFAP) and vimentin (vimentin) and its effect on the hind limbs...

2020-08-22

[Animal experiment]-The changes of telemetry EEG activity in the submarginal zone of morphine-dependent rats during the period of drug-seeking subsidence

To explore the effect and mechanism of changing the subconscious cortex (IL) telemetry EEG activity on drug-seeking behavior in the process of drug withdrawal in morphine-dependent rats...

2020-08-22

[Animal experiment]-Expression and immunolocalization of the main egg antigen Sjp40 of Schistosoma japonicum in the liver of New Zealand white rabbits

Observe the expression of Sjp40 in liver eggs of New Zealand white rabbits and the formation of granulomas, and carry out immunolocalization...

2020-08-22

[Animal experiment] -Wnt7a-Akt/mTOR signaling pathway in the improvement of skeletal muscle atrophy in CRF rats

To explore the effect and mechanism of Wnt7a-Akt/mTOR signaling pathway in improving renal failure nutritional capsules for skeletal muscle atrophy in rats with chronic renal failure (CRF)...

2020-08-22

【Animal Experiment】-The effect of chronic intermittent hypoxia on the expression of glucose transporter 4 in rat skeletal muscle

To explore the effects of inflammatory factors caused by chronic intermittent hypoxia and reoxygenation on glucose metabolism and skeletal muscle glucose transporter 4 (GLUT-4) expression in rats...

2020-08-22

[Animal experiment]-Sap2 protein and dendritic cell immune protection against systemic Candida albicans infection

Immunize mice with recombinant protein and dendritic cells (DC) to observe its protective effect on systemic Candida albicans...

2020-08-22

[Animal experiment]-Protective effect of Ulinastatin on acute lung injury in mice with severe heatstroke

Sixty SPF male C57/BL6 mice were randomly divided into 6 groups (n = 10): normal group, severe heatstroke model group, treatment group, normal saline. Simulation group and saline group after each simulated administration...

2020-08-22