气道炎症,免疫学 z-bio 2025-02-05 433

CD8+T cells specifically express granzyme K and activate complement system associated with inflammation recurrence

　　With the support of the National Natural Science Foundation of China project (approval number: T2225005), Professor Qi Hai, Associate Professor Wang Jianbin, Associate Researcher Liu Xin from Tsinghua University, and Professor Zhang Luo from Beijing Tongren Hospital have made new progress in the immunological mechanism of airway inflammation recurrence. The research results, titled "GZMK expressing CD8+T cells promote recurrent airway inflammatory diseases", were published in the journal Nature on January 15, 2025. The link to the paper is: https://doi.org/10.1038/s41586-024-08395-9 .

　　Chronic sinusitis with nasal polyps is a type of upper respiratory disease driven by allergic inflammation, with over 100 million patients in China currently. Although nasal polyps can be removed through surgery, they recur frequently and the cause is unknown. In response to the above challenges, researchers used single-cell transcriptome and lymphocyte receptor library sequencing to identify a type of memory CD8+T cells in nasal polyp tissue of patients; A new pathway for T cells to specifically express granzyme K and activate complement was identified through protein mass spectrometry; And in a mouse model of allergic asthma, the clearance of CD8+T cells by granzyme K significantly reduced lung inflammation in mice. This study reveals a novel immunological mechanism for the prolonged recurrence of allergic and airway inflammatory diseases, providing new strategies for the treatment of recurrent airway inflammation.