动物造模,药效评价,轮状病毒感染 z-bio 2024-09-25 625

　　Rotavirus belongs to the family of enteroviruses and the genus of rotavirus. The virus body is spherical in shape and has a double layered capsid, with each layer of capsid being icosahedral symmetric. The shell particles of the underwear shell are arranged radially along the edge of the virus body, resembling spokes of a wheel. It is the main pathogen causing diarrhea in infants and young children, which not only infects humans but also mammals and birds. RV infection can occur throughout the year and can cause many other diseases. The animal models for studying RV infection can be mainly divided into two categories. One is the model used solely for infection, where animals do not experience diarrhea after infection and are commonly used in adult mice or rabbits; Another type is the diarrhea model, which occurs after infection and is commonly used as animal models in young mice and piglets. Due to the low sensitivity of adult animals to RV infection, most reported studies on RV infectivity have been conducted on young animals. Previous research reports have used adult tree shrews, baboons, young monkeys, and dairy cows to conduct RV animal model studies, which have also achieved good results. The RV infection animal model is of great significance in the evaluation of preventive vaccines and therapeutic drugs.