动物造模,异种移植模型 zi-bio 2024-03-19 650

　　The establishment of a tumor xenograft model reflecting the clinical characteristics of gastric cancer is of great significance for gastric cancer research. This model has been widely applied in many fields of tumor research, including screening of new anti-tumor drugs, combination therapy trials, and tumor resistance research. Due to the good simulation of tumor growth in patients by the PDX model, which has good clinical predictability, it can be used to replace specific patients for drug screening and guide personalized anti-tumor treatment in clinical practice, namely the "Avatar" trial. Some patients have already benefited from it. Although significant progress has been made in PDX models for digestive system tumors, especially colon cancer, research on PDX models for gastric cancer is still in its early stages. It has been experimentally confirmed that the PDX model of gastric cancer maintains a high degree of consistency with the primary tumor in terms of histopathological characteristics, gene expression, and drug response. Applying it to gastric cancer research will inevitably promote new breakthroughs in personalized treatment of gastric cancer.