动物造模,动物模型 zi-bio 2024-02-27 623

　　A major challenge for many peptide or protein drug therapies is the short plasma half-life. The drugs obtained by combining these drugs with albumin are called albumin related drugs, which effectively prolong the plasma half-life. Animal models, as an important tool for studying drug pharmacokinetics, are an indispensable part of drug research.

　　This review summarizes the application and development of two major animal models: rodents (wild-type mice, rat models, genetically modified mouse models) and non rodents (monkeys) in the pharmacokinetics of albumin related drugs, providing reference for further research and development.