动物造模,动脉粥样硬化 z-bio 2023-11-10 1064

　　Method 1

　　1. Animal modeling material: Rabbit, regardless of gender; Medication: 1% acrylamide hydrochloride.

　　2. Method of modeling: Inject 1% acrylamide hydrochloride injection into the ear vein of animals at a dose of 16mg/(kg · d) for 2 consecutive weeks.

　　3. Modeling principle: Acrylamide hydrochloride causes atherosclerosis in animals.

　　After 2 weeks of modeling, there were proliferative changes in the coronary artery.

　　Method 2

　　1. Animal modeling material: Rabbit, regardless of gender; Medication: 1% acrylamide hydrochloride, pure cholesterol.

　　2. Modeling method: First, animals were given a daily dose of 1g/kg of pure cholesterol for 4 consecutive weeks. After the cholesterol rose to above 1000mg/L, 1% acrylamide hydrochloride injection was injected into the ear vein of the animals at a dose of 16mg/(kg · d) for 2 consecutive weeks.

　　3. Modeling principle: Acrylamide hydrochloride causes atherosclerosis in animals.

　　4. After modeling, the animals showed changes in the intimal surface of large myocardial branches and lesions in the main coronary artery.