动物造模,溃疡模型 z-bio 2023-10-23 820

　　1. Animal modeling materials: Male SD rats, 14 weeks old, weighing 150-200g; Medication: Ether, 1% formaldehyde solution.

　　2. Modeling method: After fasting for 24 hours and water deprivation for 2 hours, rats were subjected to mild anesthesia with ether, and their limbs and head were bound to a wooden board. They were vertically immersed in a water bath at (23 ± 0.5) ℃, with the water depth flat on the xiphoid process. Remove after 24 hours.

　　3. Modeling principle: Stress leads to animal ulcers.

　　4. Changes after modeling: After modeling, there was no pathological change in the gastric mucosa in the normal control group; The model group showed diffuse congestion, edema, and widespread distribution of points, linear ulcers, and bleeding points, most commonly seen in the gastric body and pylorus.