动物造模,手术致肠粘连模型 z-bio 2023-10-09 797

　　1. Model building materials: rats; Medications: Anesthetics, antibiotics.

　　2. Method of modeling: Before modeling, the animal fasted for 12 hours, dissected the abdomen aseptically, raised the duodenum from the pylorus, and used toothed forceps to clamp the intestinal canal 0.5cm long every 1cm, with local bleeding as the degree of bleeding. Three consecutive clamps were used. Alternatively, the same treatment can be performed on the ileum within 20cm of the ileocecal region to cause intestinal adhesions in the corresponding area.

　　3. Modeling principle: Surgery causes intestinal adhesions in animals.

　　4. The changes after modeling usually occur in the first week after surgery, which is the period of adhesion formation. There is obvious congestion and edema in the damaged area, and different degrees of adhesion can be seen between the intestinal loops and adjacent organs. The second to third weeks are the pre mechanization stage, at which the congestion and edema gradually subside, and the adhesion is more significant. At the 44th week and after, a stronger adhesion is formed.